Palo Grande is a corregimiento located in the Alanje District of the Chiriquí Province in Panama. It covers a total land area of 41.0 square kilometres (15.8 sq mi).
As of 2023, the population of Palo Grande was 642 residents, resulting in a population density of approximately 15.7 inhabitants per square kilometre. Historical data shows a steady increase in population over recent decades, rising from 563 in the year 2000 to 578 in 2010.