Vedène is a commune located in the Vaucluse department within the Provence-Alpes-Côte d'Azur region of southeastern France. It serves as a northeastern suburb of the city of Avignon.
The historical town center of Vedène is characterized by its architectural heritage, most notably the 12th-century Château de Vedène. This structure is known locally as the Château des Seigneurs and remains a dominant landmark of the area.