Priolo Gargallo is a comune located in the Province of Syracuse on the island of Sicily, Italy. It is situated approximately 190 kilometres (120 mi) southeast of Palermo and about 13 kilometres (8 mi) northwest of Syracuse.
As a municipality within the Sicilian region, Priolo Gargallo serves as a local administrative center for its surrounding area. The town's geographical position places it in close proximity to the coastal city of Syracuse.