Guspini is a town and comune located in the province of Medio Campidano within the autonomous island region of Sardinia, Italy. It serves as a municipality with a population of 10,563 inhabitants.
The town is situated approximately 62 kilometres (39 mi) from the regional capital of Cagliari and lies about 14.6 kilometres (9.1 mi) from the railway station at San Gavino Monreale.