Pozzolo Formigaro is a comune, or municipality, located in the Province of Alessandria within the Piedmont region of northern Italy. It is situated approximately 20 kilometres (12 mi) southeast of Alessandria and about 90 kilometres (56 mi) southeast of Turin.
As of January 1, 2022, the municipality covered an area of 36.18 square kilometres (13.97 mi2) with a recorded population of 4,507 residents.