Palazzolo Vercellese is a comune located in the Piedmont region of northern Italy. It is situated within the Province of Vercelli, positioned approximately 20 kilometres (12 mi) southwest of the city of Vercelli and about 45 kilometres (28 mi) northeast of Turin.
As of December 31, 2004, the municipality encompassed an area of 13.9 square kilometres (5.4 mi2) with a recorded population of 1,348 residents.