Cantalupo Ligure is a comune, or municipality, situated in the Province of Alessandria within the Piedmont region of northern Italy. It is located approximately 110 kilometres (68 mi) southeast of Turin and about 40 kilometres (25 mi) southeast of the provincial capital, Alessandria.
The town serves as a local administrative center in the rural landscape of the Piedmontese territory. Its geographic positioning places it within the historical and cultural sphere of the Alessandrian province.