Sepino is a comune located in the Province of Campobasso within the Molise region of Italy. It is situated approximately 20 kilometres, or about 12 miles, south of the provincial capital of Campobasso.
The municipality is recognized as one of the "Borghi più belli d'Italia," a designation highlighting its status as one of the most beautiful villages in the country. It serves as a notable destination within the rural landscape of the Molise region.