Pozzilli is an Italian comune situated in the Province of Isernia within the Molise region. It is located approximately 50 kilometres west of Campobasso and roughly 15 kilometres southwest of Isernia.
As a municipality, Pozzilli serves as a local administrative center within its geographic region. The town's location provides it with proximity to both the provincial capital of Isernia and the regional hub of Campobasso.