Casacalenda is a comune, or municipality, situated in the Italian region of Molise. It is located within the Province of Campobasso and sits approximately 25 kilometres (16 mi) northeast of the provincial capital, Campobasso.
The town serves as a local administrative center within its province. Its geographical position places it in the heart of the Molise region, characterized by its proximity to major regional hubs like Campobasso.