Monteprandone is a comune, or municipality, located in the Marche region of central Italy. It is situated within the Province of Ascoli Piceno, positioned approximately 80 kilometres southeast of Ancona and about 20 kilometres northeast of its provincial capital, Ascoli Piceno.
The town is historically significant as the birthplace of James of the Marches. Beyond its geographical location in the Marche region, it serves as a recognized administrative center within the province.