Massignano is a comune, or municipality, located in the Marche region of central Italy. It is situated within the Province of Ascoli Piceno, positioned approximately 70 kilometres southeast of Ancona and about 30 kilometres northeast of Ascoli Piceno.
As of December 31, 2004, the municipality covered an area of 16.3 square kilometres and had a recorded population of 1,621 residents.