Colli del Tronto is a comune located in the Province of Ascoli Piceno within the Marche region of central Italy. It is situated approximately 80 kilometres south of Ancona and about 14 kilometres northeast of the provincial capital, Ascoli Piceno.
As of December 31, 2004, the municipality encompassed an area of 5.9 square kilometres and had a recorded population of 3,290 residents.