Sesto ed Uniti is a comune, or municipality, located in the Province of Cremona within the Lombardy region of northern Italy. It is situated approximately 70 kilometres southeast of Milan and about 11 kilometres northwest of the city of Cremona.
The town serves as a local administrative center in the province. Its geographical position places it within the heart of the Lombardy region, characterized by its proximity to major regional hubs like Milan and Cremona.