Pessina Cremonese is a comune, or municipality, situated in the Province of Cremona within the Italian region of Lombardy. It is located approximately 90 kilometres southeast of Milan and about 20 kilometres northeast of the city of Cremona.
The town serves as a local administrative center in the rural landscape of the province. Its geographic position places it within the heart of the Lombardy region, characterized by its proximity to major regional hubs like Milan and the provincial capital.