Poggio Bustone is a comune, or municipality, situated in the Province of Rieti within the Italian region of Latium. It is located approximately 70 kilometres northeast of Rome and about 11 kilometres north of the city of Rieti.
The municipality serves as a local administrative division in the central Italian landscape. Its geographical position places it within the rural surroundings of the Rieti province, characterized by its proximity to regional transport hubs and neighboring towns.