Vezzano sul Crostolo is a comune, or municipality, situated in the Province of Reggio Emilia within the Italian region of Emilia-Romagna. It is located approximately 60 kilometres west of Bologna and about 13 kilometres southwest of the city of Reggio Emilia.
The town serves as a local administrative center in the northern part of Italy, positioned within the geographical boundaries of the Reggio Emilia province.