San Lorenzello is a comune, or municipality, located in the Province of Benevento within the Campania region of southern Italy. It is situated approximately 25 kilometres (16 mi) northwest of the city of Benevento and lies northeast of Naples.
The town serves as a local administrative center within its province. Its geographic positioning places it in the inland area of the Campania region, characterized by its proximity to major regional hubs like Benevento and the coastal city of Naples.