Castelmezzano is a town and comune located in the province of Potenza within the Southern Italian region of Basilicata. It is situated in an area bounded by the comuni of Albano di Lucania, Anzi, Laurenzana, Pietrapertosa, and Trivigno.
The municipality serves as a notable geographical point in the Basilicata region, characterized by its specific administrative boundaries within the province of Potenza.