Santo Stefano di Sessanio is a comune and medieval hill town situated in the province of L'Aquila within the Abruzzo region of southern Italy. It is located in the high Apennines, specifically inside the Gran Sasso e Monti della Laga National Park.
The town sits adjacent to the high plain of Campo Imperatore and is recognized as one of the "Borghi più belli d'Italia," a designation highlighting its status as one of Italy's most beautiful villages.