San Benedetto in Perillis is a town and comune located in the province of L'Aquila within the Abruzzo region of central Italy. It is situated approximately 43 kilometres (27 mi) from the regional capital city of L'Aquila.
The municipality serves as a local administrative center in the mountainous landscape of the Abruzzo region. It is characterized by its position within the provincial territory governed by L'Aquila.