San Antonio Palopó is a municipality located in the Sololá Department of Guatemala. Situated on the eastern shore of Lake Atitlán, the village reaches its lowest elevation of 1,562 metres (5,125 ft) at the shoreline.
The region is inhabited by Cakchiquel Maya people, who are known for their distinctive style of clothing. The community observes an annual festival on June 13 in honor of its patron saint, St. Anthony of Padua.