Palamas is a town and municipality located in the Karditsa regional unit of Greece. It is situated in the Thessaly region, positioned south-southwest of Larissa, which serves as the regional capital.
The town's geography is defined by its proximity to several neighboring areas, including Lamia to the northwest, Sofades to the north, Karditsa to the east-northeast, and Trikala to the east-southeast. The Pineios River flows to the north of Palamas, bordering the Trikala regional unit.