Aspley Guise is a village and civil parish located in the west of Central Bedfordshire, England. The civil parish encompasses the village of Aspley Guise as well as a portion of the town of Woburn Sands, while the remainder of Woburn Sands falls within the City of Milton Keynes in Buckinghamshire.
The area forms part of the Milton Keynes urban area and is situated approximately 6 miles east southeast of Central Milton Keynes and 1 mile south of the M1 junction 13. Notable features of the village include its own railway station on the Marston Vale Line and an historic centre containing 29 listed buildings.