Rui Vaz is a settlement located in the central region of the island of Santiago in Cape Verde. It is situated at an elevation of 809 meters above sea level and falls under the jurisdiction of the municipality of São Domingos.
The settlement is positioned approximately 2 kilometers south of São Jorge dos Órgãos and 4 kilometers west of São Domingos. As of 2010, Rui Vaz had a recorded population of 1,078 residents.