Sefophe is a village situated in the Central District of Botswana. It is located approximately 27 km south-east of the mining town of Selebi-Phikwe and sits within 100 km of the borders shared with Zimbabwe and South Africa.
According to the 2011 census, the population of Sefophe was 6,062. The village serves as a residential area in the central region of the country.