Rondonópolis is a city located in the Mato Grosso region of Brazil. It serves as the third-largest municipality within the state. The city is situated approximately 215 km (134 mi) from Cuiabá, which is the capital of Mato Grosso.
The municipality was named in honor of Cândido Rondon, a notable military officer and explorer. It functions as a significant regional center within its geographic area.