Presidencia Roque Sáenz Peña is a city located in the Chaco province of Argentina. It serves as the second largest city within the province and is situated approximately 170 kilometres (110 mi) west-northwest of the provincial capital, Resistencia.
The city lies on the primary rail and road route that traverses northern Argentina toward Salta. According to recent data, the urban area of the locality has a population of 76,377, while the total municipality population is 88,164.