St. Johnston is a settlement located in the northwest region of the island of Antigua. Situated just east of the capital city, St. John's, it functions virtually as a suburb of the urban center. The village is bordered by Potters Village, which lies immediately to its southeast.
The area was named in honor of Sir Thomas Reginald St. Johnston, who served as the Governor General of the Leeward Islands. He is notably associated with the location for having constructed a hospital there.